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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:37659
Term: oleanolic acid
Definition: A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Chemical ID: MESH:D009828
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDOleanolic Acid analog results in decreased phosphorylation of MAPK1 protein; Oleanolic Acid results in decreased phosphorylation of MAPK1 proteinPMID:26612655 PMID:35690101
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDOleanolic Acid results in increased phosphorylation of MAPK1 proteinPMID:36846903
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDOleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK1 protein modified form]PMID:20100471
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDOleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Oleanolic Acid results in increased phosphorylation of MAPK1 protein]PMID:31306688 PMID:36846903
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