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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:37187
Term: lead nitrate
Definition: A lead coordination entity that has formula N2O6Pb.
Chemical ID: MESH:C017461
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDlead nitrate results in increased phosphorylation of MAPK1 proteinPMID:20850495 PMID:22502979
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDlead nitrate results in increased phosphorylation of MAPK1 proteinPMID:23451106
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]PMID:20850495
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDmangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]PMID:23451106
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