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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1affects expressionEXP 6480464CTDlead acetate affects the expression of MAPK1PMID:24293362
Mapk1decreases phosphorylationEXP 6480464CTDlead acetate results in decreased phosphorylation of MAPK1 proteinPMID:25981801
Mapk1increases expressionEXP 6480464CTDlead acetate results in increased expression of MAPK1 mRNAPMID:33862172
Mapk1increases phosphorylationEXP 6480464CTDlead acetate results in increased phosphorylation of MAPK1 proteinPMID:22728154 PMID:26797587 PMID:26926986
Mapk1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of MAPK1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPK1 protein; Ascorbic Acid inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; lead acetate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Quercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]PMID:11233754 PMID:17298174 PMID:20829427 PMID:22728154 PMID:26797587 PMID:34350654 PMID:35307918 PMID:39276841
Mapk1increases oxidationISOMAPK1 (Homo sapiens)6480464CTDlead acetate results in increased oxidation of MAPK1 protein; lead acetate results in increased oxidation of MAPK1 protein modified formPMID:23370007
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDlead acetate results in increased phosphorylation of MAPK1 proteinPMID:15302094 PMID:19133285 PMID:23370007 PMID:23765435 PMID:26542248
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDlead acetate results in increased phosphorylation of MAPK1 proteinPMID:23855546 PMID:24530660 PMID:37385299
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; [E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK1 protein modified form]] which results in decreased phosphorylation of MAPK1 protein modified form; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; E 3330 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK1 protein modified form]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK1 protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK1 protein]; lead acetate promotes the reaction [MAPK1 protein modified form binds to APEX1 protein]; lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]PMID:11861786 PMID:15302094 PMID:19133285 PMID:23370007 PMID:23765435
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTD3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]PMID:23855546 PMID:37385299
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