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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDVitamin K 3 results in increased phosphorylation of MAPK1 proteinPMID:11880281 PMID:16310883
Mapk1multiple interactionsEXP 6480464CTDMn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]PMID:11880281 PMID:16310883
Mapk1increases activityISOMapk1 (Mus musculus)6480464CTDVitamin K 3 results in increased activity of MAPK1 proteinPMID:21250784
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDVitamin K 3 results in increased phosphorylation of MAPK1 proteinPMID:16996477
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDVitamin K 3 results in increased phosphorylation of MAPK1 proteinPMID:16507596
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]PMID:16996477
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDschizandrin B promotes the reaction [Vitamin K 3 results in increased activity of MAPK1 protein]PMID:21250784
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