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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:191411
Term: taiwanin C
Definition: A furonaphthodioxole that is furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one substituted by a 1,3-benzodioxol-5-yl group at position 5. It is a naturally occurring lignan extracted from Taiwania cryptomerioides and found to be a potential inhibitor of COX2 expression.
Chemical ID: MESH:C467766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDtaiwanin C results in decreased phosphorylation of MAPK1 proteinPMID:26537528
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDTetradecanoylphorbol Acetate inhibits the reaction [taiwanin C results in decreased phosphorylation of MAPK1 protein]PMID:26537528
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