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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:17447
Term: geraniol
Definition: A monoterpenoid consisting of two prenyl units linked head-to-tail and functionalised with a hydroxy group at its tail end.
Chemical ID: MESH:C007836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDgeraniol results in decreased phosphorylation of MAPK1 proteinPMID:12388655
Mapk1decreases phosphorylationISOMapk1 (Mus musculus)6480464CTDgeraniol results in decreased phosphorylation of MAPK1 proteinPMID:26154255
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDgeraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased phosphorylation of MAPK1 protein]PMID:22760862
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