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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1decreases expressionISOMAP2K1 (Homo sapiens)6480464CTDCocaine results in decreased expression of MAP2K1 mRNAPMID:12629581
Map2k1increases phosphorylationISOMap2k1 (Mus musculus)6480464CTDCocaine results in increased phosphorylation of MAP2K1 proteinPMID:15665076
Map2k1multiple interactionsISOMap2k1 (Mus musculus)6480464CTDCDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein]PMID:15665076
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