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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70487
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1affects localizationEXP 6480464CTDDiethylnitrosamine affects the localization of CTNNB1 protein modified formPMID:21554863
Ctnnb1increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of CTNNB1 mRNAPMID:21554863
Ctnnb1increases mutagenesisEXP 6480464CTDDiethylnitrosamine results in increased mutagenesis of CTNNB1PMID:10463579
Ctnnb1multiple interactionsEXP 6480464CTD5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]PMID:21554863
Ctnnb1decreases response to substanceISOCtnnb1 (Mus musculus)6480464CTDCTNNB1 protein results in decreased susceptibility to DiethylnitrosaminePMID:20583210
Ctnnb1increases expressionISOCtnnb1 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of CTNNB1 mRNA; Diethylnitrosamine results in increased expression of CTNNB1 proteinPMID:20583210 PMID:27058323
Ctnnb1multiple interactionsISOCtnnb1 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Dietary Fats] results in increased expression of and results in increased phosphorylation of CTNNB1 protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased mutagenesis of CTNNB1 gene; [Diethylnitrosamine promotes the reaction [TGFB1 protein affects the susceptibility to Dietary Fats]] which results in increased expression of CTNNB1 protein; [Phenobarbital co-treated with Diethylnitrosamine] results in increased mutagenesis of CTNNB1 gene; CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]; CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein]; CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein]; CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein]; CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of PDK1 protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of EGFR protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of HGF protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of HGFAC protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of MET protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of FAS protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of NFKB1 protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of NFKBIA protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of RELA protein]; CTNNB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of TRAF1 protein]; epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]; epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA]; theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 protein]PMID:20583210 PMID:21047994 PMID:24535843 PMID:27058323 PMID:30826251
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