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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69408
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lcn2
Name: lipocalin 2
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lcn2increases expressionISOLcn2 (Mus musculus)6480464CTDFolic Acid results in increased expression of LCN2 mRNA; Folic Acid results in increased expression of LCN2 proteinPMID:23255615 PMID:38272249
Lcn2multiple interactionsISOLcn2 (Mus musculus)6480464CTDEGFR protein affects the reaction [Folic Acid results in increased expression of LCN2 protein]; Folic Acid inhibits the reaction [Doxorubicin results in increased expression of LCN2 mRNA]; Gefitinib promotes the reaction [Folic Acid results in increased expression of LCN2 protein]; icariin inhibits the reaction [Folic Acid results in increased expression of LCN2 mRNA]PMID:23255615 PMID:28608983 PMID:38272249
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