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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69408
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lcn2
Name: lipocalin 2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lcn2increases expressionISOLCN2 (Homo sapiens)6480464CTDOzone results in increased expression of LCN2 mRNAPMID:23033980
Lcn2increases expressionISOLcn2 (Mus musculus)6480464CTDOzone results in increased expression of LCN2 mRNA; Ozone results in increased expression of LCN2 proteinPMID:12763052 PMID:17095637 PMID:22300504 PMID:25658374 PMID:30848106 PMID:33026818
Lcn2multiple interactionsISOLcn2 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of LCN2 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of LCN2 mRNA; [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of LCN2 mRNA; Ozone results in increased expression of and results in increased secretion of LCN2 protein; TTPA protein affects the reaction [Ozone results in increased expression of LCN2 mRNA]PMID:19555225 PMID:25658374 PMID:27106289 PMID:28381600 PMID:34911549
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