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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CDKN1A proteinPMID:33581290
Cdkn1aaffects expressionISOCdkn1a (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether affects the expression of CDKN1A mRNAPMID:30294300
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDKN1A mRNAPMID:26988655
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTD[Flame Retardants results in increased abundance of 2,2',4,4'-tetrabromodiphenyl ether] which affects the expression of CDKN1A proteinPMID:38995820
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