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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aaffects expressionISOCDKN1A (Homo sapiens)6480464CTDCannabidiol affects the expression of CDKN1A mRNAPMID:38342230
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDCannabidiol results in decreased expression of CDKN1A mRNAPMID:27918106
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDCannabidiol results in increased expression of CDKN1A mRNAPMID:21542829 PMID:30742662 PMID:31052254
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDCannabidiol results in increased expression of CDKN1A mRNA; Cannabidiol results in increased expression of CDKN1A proteinPMID:31349651 PMID:36519830
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Cannabidiol] results in increased expression of CDKN1A mRNAPMID:30742662
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[Cannabidiol co-treated with moringin] results in decreased expression of CDKN1A mRNAPMID:30096889
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