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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDPaclitaxel results in decreased expression of CDKN1A mRNAPMID:24211769
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDPaclitaxel results in increased expression of CDKN1A mRNA; Paclitaxel results in increased expression of CDKN1A proteinPMID:12929121 PMID:9231689
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTD[Paclitaxel results in increased expression of TP53 protein] which results in increased expression of CDKN1A mRNA; Paclitaxel results in increased expression of CDKN1A proteinPMID:16601104 PMID:18516295 PMID:9041188
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[Cisplatin co-treated with Paclitaxel] results in increased expression of CDKN1A mRNA; [Doxorubicin co-treated with Paclitaxel] results in increased expression of CDKN1A protein; [PD168393 co-treated with Paclitaxel] results in increased expression of CDKN1A protein; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]PMID:16168113 PMID:16413505 PMID:16601104 PMID:18516295 PMID:20705681
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