GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1a | increases expression | EXP | | 6480464 | CTD | Curcumin results in increased expression of CDKN1A protein | PMID:17602960 PMID:18316600 | Cdkn1a | multiple interactions | EXP | | 6480464 | CTD | Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein] | PMID:17602960 | Cdkn1a | decreases expression | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein | PMID:17148446 PMID:17332326 PMID:18593936 PMID:30935902 | Cdkn1a | increases expression | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA | PMID:15738001 PMID:25822711 | Cdkn1a | increases expression | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein | PMID:15713895 PMID:18156803 PMID:18161303 PMID:18226269 PMID:18316600 PMID:23222814 PMID:25644192 PMID:33582110 | Cdkn1a | multiple interactions | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CDKN1A mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein] | PMID:28681665 PMID:38301994 | Cdkn1a | multiple interactions | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein] | PMID:18226269 PMID:18316600 PMID:20153625 PMID:23222814 PMID:27132804 PMID:27430728 PMID:30935902 | | ||||||||||||||||||||||
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