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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aaffects expressionEXP 6480464CTDDoxorubicin affects the expression of CDKN1A mRNAPMID:12187937
Cdkn1aincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of CDKN1A mRNA; Doxorubicin results in increased expression of CDKN1A proteinPMID:15124910 PMID:18031568 PMID:27181935 PMID:32289291 PMID:38395252
Cdkn1amultiple interactionsEXP 6480464CTDFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; GW 6471 inhibits the reaction [SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]PMID:27181935 PMID:38395252
Cdkn1aaffects expressionISOCDKN1A (Homo sapiens)6480464CTDDoxorubicin affects the expression of CDKN1A mRNA; Doxorubicin affects the expression of CDKN1A proteinPMID:17893511 PMID:25529476 PMID:31470548
Cdkn1aaffects response to substanceISOCDKN1A (Homo sapiens)6480464CTDCDKN1A affects the susceptibility to DoxorubicinPMID:15492826
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of CDKN1A proteinPMID:14601052
Cdkn1adecreases response to substanceISOCdkn1a (Mus musculus)6480464CTDCDKN1A results in decreased susceptibility to DoxorubicinPMID:21920376
Cdkn1aincreases activityISOCDKN1A (Homo sapiens)6480464CTDDoxorubicin results in increased activity of CDKN1A proteinPMID:15141020
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDDoxorubicin results in increased expression of CDKN1A mRNA; Doxorubicin results in increased expression of CDKN1A proteinPMID:16013437 PMID:16432175 PMID:16949053 PMID:21040762 PMID:21920376 PMID:22712078 PMID:24439385 PMID:25896364 PMID:28608983 PMID:28710503 PMID:36227756 PMID:38395252
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDDoxorubicin results in increased expression of CDKN1A; Doxorubicin results in increased expression of CDKN1A mRNA; Doxorubicin results in increased expression of CDKN1A proteinPMID:12006519 PMID:14665630 PMID:15205334 PMID:15555623 PMID:15601469 PMID:15781256 PMID:16439685 PMID:16537896 PMID:16705698 PMID:16857806 PMID:17653088 PMID:17682292 PMID:17974990 PMID:18347191 PMID:19074854 PMID:19351845 PMID:20346999 PMID:22927544 PMID:24816189 PMID:26025680 PMID:26320837 PMID:26969377 PMID:28507149 PMID:29803840 PMID:30258081 PMID:32562081 PMID:34719826 PMID:34783124 PMID:36634904
Cdkn1aincreases response to substanceISOCDKN1A (Homo sapiens)6480464CTDCDKN1A protein results in increased susceptibility to DoxorubicinPMID:15601469 PMID:22927544
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTD[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of CDKN1A mRNA; CDKN1A gene mutant form inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]; CDKN1A gene mutant form inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]; CDKN1A gene mutant form inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; CDKN1A gene mutant form inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; CDKN1A gene mutant form inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA]; CDKN1A gene mutant form inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; TRP53 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]PMID:16013437 PMID:21040762 PMID:21920376 PMID:22712078 PMID:38395252
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD1-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; [dimethyl sulfone co-treated with Doxorubicin] affects the expression of CDKN1A mRNA; [Doxorubicin co-treated with Paclitaxel] results in increased expression of CDKN1A protein; [Doxorubicin co-treated with Resveratrol] results in increased expression of CDKN1A mRNA; [Doxorubicin co-treated with Resveratrol] results in increased expression of CDKN1A protein; [RELA protein affects the expression of CDKN1A protein] which affects the susceptibility to Doxorubicin; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; bisphenol A affects the reaction [Doxorubicin affects the expression of CDKN1A mRNA]; bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; CDC25C protein inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; CDKN1A protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; CDKN1A protein results in decreased susceptibility to [Doxorubicin co-treated with TNF protein]; CGK 733 inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Chloroquine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; dimethyl sulfone affects the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; Doxorubicin affects the reaction [RELA protein binds to CDKN1A promoter]; Doxorubicin affects the reaction [RELA protein results in increased expression of CDKN1A mRNA]; Doxorubicin inhibits the reaction [KDM8 protein binds to CDKN1A promoter]; Doxorubicin promotes the reaction [TP53 protein binds to CDKN1A promoter]; Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein; FHL2 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of CDKN1A protein]; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; Glutathione inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; KDM8 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]; RV 538 inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; SPHK2 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]; tempol promotes the reaction [CDKN1A protein results in increased susceptibility to Doxorubicin]; TNF protein inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; TP53 affects the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [Doxorubicin affects the reaction [RELA protein results in increased expression of CDKN1A mRNA]]; TP53 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [FHL2 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]]; TP53 protein mutant form affects the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; TRIM28 protein modified form inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; XAF1 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]PMID:15601469 PMID:15781256 PMID:15823547 PMID:16168113 PMID:16909308 PMID:17079232 PMID:17682292 PMID:17974990 PMID:18269916 PMID:18347191 PMID:19074854 PMID:19351845 PMID:21624110 PMID:22927544 PMID:24816189 PMID:26025680 PMID:26320837 PMID:26969377 PMID:28507149 PMID:30258081 PMID:31470548 PMID:32562081 PMID:34719826 PMID:34783124
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