A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID:
MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A protein]
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDKN1A mRNA; [Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1A protein]]] which results in decreased activity of CDK2 protein; [Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]] which results in decreased activity of CDK2 protein; AHR affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1A mRNA]; NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1A mRNA]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1A protein]]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1A protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]; [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDKN1A mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [CDKN1A protein binds to CCND1 protein]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1A protein]; Mifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]; PGR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in decreased expression of CDKN1A protein]; Tetrachlorodibenzodioxin promotes the reaction [CDKN1A protein binds to CCND1 protein]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol inhibits the reaction [CDK2 protein binds to CDKN1A protein]]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol inhibits the reaction [CDK4 protein binds to CDKN1A protein]]; Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of CDKN1A mRNA]; Tetrachlorodibenzodioxin results in decreased expression of and results in decreased activity of CDKN1A protein; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
