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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionEXP 6480464CTDOzone results in increased expression of CDKN1A mRNAPMID:28623178 PMID:31397875 PMID:33662111 PMID:35737395
Cdkn1amultiple interactionsEXP 6480464CTD[Ozone co-treated with Chlorine] affects the expression of CDKN1A mRNAPMID:18636392
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDOzone results in increased expression of CDKN1A mRNAPMID:17460151 PMID:20123758
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDOzone results in increased expression of CDKN1A mRNAPMID:28652203 PMID:31476115
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTD[Acetaminophen co-treated with Ozone] results in increased expression of CDKN1A mRNAPMID:20123758
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CDKN1A mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CDKN1A mRNA; [Aripiprazole co-treated with Ozone] results in increased expression of CDKN1A mRNA; [Volatile Organic Compounds co-treated with Ozone] results in increased oxidation of CDKN1A mRNAPMID:31476115 PMID:32699268
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