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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDCalcitriol results in increased expression of CDKN1A; Calcitriol results in increased expression of CDKN1A mRNA; Calcitriol results in increased expression of CDKN1A proteinPMID:10825140 PMID:11270487 PMID:11519864 PMID:12071473 PMID:16039115 PMID:16434701 PMID:21542014 PMID:33033332 PMID:34025784 PMID:35914560 PMID:36504884 PMID:9348195 PMID:9783903
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Calcitriol] results in increased expression of CDKN1A mRNA; [Arsenic Trioxide co-treated with Calcitriol] results in increased expression of CDKN1A protein; [Calcitriol co-treated with Genistein] results in increased expression of CDKN1A mRNA; [salinomycin co-treated with Calcitriol] results in increased expression of CDKN1A mRNA; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDKN1A mRNA]; Calcitriol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDKN1A protein]; perfluorooctanoic acid inhibits the reaction [Calcitriol results in increased expression of CDKN1A mRNA]PMID:15955619 PMID:33033332 PMID:34025784 PMID:35914560 PMID:36504884
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