GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1a | decreases expression | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | Nicotine results in decreased expression of CDKN1A protein | PMID:18805435 PMID:30272249 | Cdkn1a | increases expression | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Nicotine results in increased expression of CDKN1A mRNA; Nicotine results in increased expression of CDKN1A protein | PMID:31507073 PMID:32473187 | Cdkn1a | increases expression | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | Nicotine results in increased expression of CDKN1A protein | PMID:16011614 PMID:20727180 | Cdkn1a | multiple interactions | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein] | PMID:32473187 | Cdkn1a | multiple interactions | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1A protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein] | PMID:16601104 PMID:18805435 | | ||||||||||||||||||||||
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