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GENE - TERM ANNOTATION REPORT

RGD ID: 69259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Axin2
Name: axin 2
Acc ID: GO:0090090
Term: negative regulation of canonical Wnt signaling pathway
Definition: Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
Definition Source(s): GOC:dph, GOC:tb
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Axin2involved_inISOAXIN2 (Homo sapiens)1624291RGD PMID:11017067 PMID:11940574 PMID:16247484

PMID:11017067 PMID:11940574 PMID:16247484
Axin2involved_inISOAxin2 (Mus musculus)1624291RGD PMID:28069701

PMID:28069701
Axin2involved_inIEAUniProtKB:O88566 or ensembl:ENSMUSP000000513311600115EnsemblGO_REF:0000107

GO_REF:0000107
Axin2involved_inIEAUniProtKB:Q9Y2T1 or ensembl:ENSP000003026251600115EnsemblGO_REF:0000107

GO_REF:0000107
Axin2involved_inIBAFB:FBgn0026597 or MGI:1096327 or MGI:1270862 or PANTHER:PTN002918813 or Axin1 (Rattus norvegicus) or UniProtKB:O15169 or UniProtKB:Q9Y2T1 or ZFIN:ZDB-GENE-000403-1 or ZFIN:ZDB-GENE-000403-21600115GO_CentralGO_REF:0000033

GO_REF:0000033
Axin2involved_inIEAInterPro:IPR0435811600115InterProGO_REF:0000002

GO_REF:0000002
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