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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69226
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4decreases expressionISOGPX4 (Homo sapiens)6480464CTDParaquat results in decreased expression of GPX4 proteinPMID:37507096
Gpx4decreases response to substanceISOGpx4 (Mus musculus)6480464CTDGPX4 protein results in decreased susceptibility to ParaquatPMID:12566075
Gpx4increases expressionISOGpx4 (Mus musculus)6480464CTDParaquat results in increased expression of GPX4 mRNAPMID:12732627
Gpx4increases response to substanceISOGpx4 (Mus musculus)6480464CTDGPX4 gene mutant form results in increased susceptibility to ParaquatPMID:12566075
Gpx4multiple interactionsISOGPX4 (Homo sapiens)6480464CTD[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein; NFE2L2 protein inhibits the reaction [Paraquat results in decreased expression of GPX4 protein]PMID:30797899 PMID:37507096
Gpx4multiple interactionsISOGpx4 (Mus musculus)6480464CTD[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein]PMID:30797899
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