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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGdecreases expressionISOPparg (Mus musculus)6480464CTDSB 203580 results in decreased expression of PPARG mRNA; SB 203580 results in decreased expression of PPARG proteinPMID:23603106
PPARGincreases expressionISOPparg (Rattus norvegicus)6480464CTDSB 203580 results in increased expression of PPARG mRNA; SB 203580 results in increased expression of PPARG proteinPMID:24412557
PPARGmultiple interactionsISOPparg (Rattus norvegicus)6480464CTDSB 203580 inhibits the reaction [Ethanol results in decreased expression of PPARG protein]PMID:24412557
PPARGmultiple interactionsISOPparg (Mus musculus)6480464CTD[SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of PPARG protein alternative form]PMID:14984747
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