GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PPARG | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of PPARG protein | PMID:30362509 | PPARG | decreases response to substance | EXP | | 6480464 | CTD | PPARG protein results in decreased susceptibility to Arsenic Trioxide | PMID:20707922 | PPARG | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of PPARG mRNA; Arsenic Trioxide results in increased expression of PPARG protein | PMID:22684020 PMID:34108876 | PPARG | multiple interactions | EXP | | 6480464 | CTD | [Rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased susceptibility to Arsenic Trioxide; [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of PPARG protein; [Troglitazone binds to and results in increased activity of PPARG protein] which results in increased susceptibility to Arsenic Trioxide; Arsenic Trioxide results in increased expression of and results in decreased activity of PPARG protein; KEAP1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of PPARG mRNA]; KEAP1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of PPARG protein]; NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of PPARG mRNA]; Rosiglitazone inhibits the reaction [Arsenic Trioxide results in decreased expression of PPARG protein]; Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PPARG protein] | PMID:22684020 PMID:30362509 PMID:32929351 | PPARG | decreases expression | ISO | Pparg (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of PPARG mRNA | PMID:31258454 | PPARG | decreases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of PPARG protein | PMID:15916724 PMID:30362509 | PPARG | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | Arsenic Trioxide inhibits the reaction [AKT1 protein binds to PPARG protein]; Arsenic Trioxide inhibits the reaction [RXRA protein binds to PPARG protein]; Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PPARG protein] | PMID:15916724 PMID:30362509 | | ||||||||||||||||||||||
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