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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:81781
Term: tebuconazole
Definition: A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops.
Chemical ID: MESH:C087114
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2increases activityEXP 6480464CTDtebuconazole results in increased activity of NR1I2 proteinPMID:28728110 PMID:29420809 PMID:36291160
NR1I2multiple interactionsEXP 6480464CTD[tebuconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; tebuconazole binds to and results in increased activity of NR1I2 proteinPMID:29420809 PMID:33049310
NR1I2multiple interactionsISONr1i2 (Mus musculus)6480464CTDtebuconazole binds to and results in increased activity of NR1I2 proteinPMID:33049310
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