GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NR1I2 | increases activity | EXP | | 6480464 | CTD | Paclitaxel results in increased activity of NR1I2 protein | PMID:12065438 PMID:15650019 PMID:16819505 PMID:20041327 | NR1I2 | multiple interactions | EXP | | 6480464 | CTD | [Paclitaxel results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [SR 12813 results in increased activity of NR1I2 protein] which results in decreased susceptibility to Paclitaxel; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; NR1I2 protein promotes the reaction [Paclitaxel results in increased expression of and results in increased activity of ABCB1 protein]; Paclitaxel binds to and results in increased activity of NR1I2 protein; Paclitaxel promotes the reaction [NR1I2 protein binds to MED1 protein]; Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA3 protein] | PMID:14977870 PMID:15650019 PMID:15864135 PMID:16819505 PMID:18839173 PMID:19746521 PMID:20041327 | NR1I2 | increases abundance | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | NR1I2 gene mutant form results in increased abundance of Paclitaxel | PMID:17438109 | | ||||||||||||||||||||||
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