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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:18358
Term: methoxsalen
Definition: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Chemical ID: MESH:D008730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2increases activityEXP 6480464CTDMethoxsalen results in increased activity of NR1I2 proteinPMID:17003103 PMID:25455453
NR1I2multiple interactionsEXP 6480464CTDNR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]PMID:17003103
NR1I2increases activityISONr1i2 (Rattus norvegicus)6480464CTDMethoxsalen results in increased activity of NR1I2 proteinPMID:17003103
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