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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:50692
Term: mifepristone
Definition: A 3-oxo steroid that has formula 429.59374.
Chemical ID: MESH:D015735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1bincreases expressionISOCDKN1B (Homo sapiens)6480464CTDMifepristone results in increased expression of CDKN1B mRNA; Mifepristone results in increased expression of CDKN1B proteinPMID:34537908
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTDMifepristone inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of CDKN1B protein]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of CDKN1B mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of CDKN1B protein]; Mifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]; Mifepristone promotes the reaction [CDK2 protein binds to CDKN1B protein]; Mifepristone promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]; Mifepristone results in increased expression of and results in increased localization of CDKN1B proteinPMID:17283133 PMID:17545545 PMID:22266097 PMID:34537908
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