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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:81927
Term: enilconazole
Definition: A racemate comprising equimolar amounts of (R)- and (S)-enilconazole. A fungicide used to control a wide range of fungi including Tilletia and Helminthosporium spp. on fruit, vegetables and ornamentals. In veterinary medicine, it is used topically for the treatment of fungal skin infections in cattle, dogs, and horses; it is also used by inhalation for the treatment of aspergillosis in ostriches.
Chemical ID: MESH:C017435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDenilconazole results in increased activity of NR1I2 proteinPMID:16565514
Nr1i2increases activityISONr1i2 (Mus musculus)6480464CTDenilconazole results in increased activity of NR1I2 proteinPMID:29973476
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[enilconazole co-treated with methidathion] results in increased activity of NR1I2 protein; enilconazole binds to and results in increased activity of NR1I2 protein; enilconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]PMID:17438109 PMID:21115097 PMID:25028461 PMID:33049310
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDenilconazole binds to and results in increased activity of NR1I2 proteinPMID:21115097 PMID:33049310
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