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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:29014
Term: cordycepin
Definition: A 3'-deoxyribonucleoside that has formula C10H13N5O3.
Chemical ID: MESH:C058120
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsEXP 6480464CTD[cordycepin co-treated with TGFB1 protein] affects the expression of HGF mRNA; [cordycepin co-treated with TGFB1 protein] affects the phosphorylation of MET protein; [cordycepin co-treated with TGFB1 protein] affects the secretion of HGF protein; cordycepin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; cordycepin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; HGF protein inhibits the reaction [cordycepin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; HGF protein inhibits the reaction [cordycepin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]]PMID:22134049
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDcordycepin results in increased expression of TGFB1 mRNAPMID:34070360
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDcordycepin results in increased expression of and results in increased secretion of TGFB1 proteinPMID:34070360
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