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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:132471
Term: (+)-schisandrin B
Definition: An organic heterotetracyclic compound that is found in Fructus Schisandrae and Schisandra chinensis.
Chemical ID: MESH:C015499
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsEXP 6480464CTDschizandrin B inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; schizandrin B inhibits the reaction [TGFB1 protein results in decreased expression of MIR30E mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of ZEB2 mRNA]PMID:31697999
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTD[schizandrin B co-treated with TGFB1 protein] results in decreased expression of SNAI2 protein; [schizandrin B co-treated with TGFB1 protein] results in decreased expression of ZEB2 protein; MIR30E mRNA affects the reaction [schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; MIR30E mRNA affects the reaction [schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 mRNA]]; schizandrin B affects the reaction [TGFB1 protein results in decreased expression of MIR30B mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; schizandrin B inhibits the reaction [TGFB1 protein results in decreased expression of MIR30E mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 mRNA]; schizandrin B promotes the reaction [TGFB1 protein results in decreased expression of MIR30D mRNA]PMID:31697999
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