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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68946
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Penk
Name: proenkephalin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Penkaffects expressionISOPENK (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of PENK mRNAPMID:36370075
Penkincreases expressionISOPenk (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of PENK mRNAPMID:16922920
Penkmultiple interactionsISOPenk (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PENK mRNAPMID:17942748
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