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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68534
Species: Mus musculus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:6887
Term: methylphenidate
Definition: A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
Chemical ID: MESH:D008774
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtoraffects expressionISOMtor (Rattus norvegicus)6480464CTDMethylphenidate affects the expression of MTOR mRNAPMID:21753012
Mtorincreases expressionISOMtor (Rattus norvegicus)6480464CTDMethylphenidate results in increased expression of MTOR mRNAPMID:32746681
Mtormultiple interactionsISOMtor (Rattus norvegicus)6480464CTD[Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR proteinPMID:21753012
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