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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68534
Species: Mus musculus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtordecreases phosphorylationEXP 6480464CTDChlorpyrifos results in decreased phosphorylation of MTOR proteinPMID:34289071
Mtormultiple interactionsEXP 6480464CTD[Paraquat co-treated with Chlorpyrifos] results in increased expression of MTOR proteinPMID:26884967
Mtorincreases expressionISOMtor (Rattus norvegicus)6480464CTDChlorpyrifos results in increased expression of MTOR mRNA; Chlorpyrifos results in increased expression of MTOR proteinPMID:35439518
Mtormultiple interactionsISOMtor (Rattus norvegicus)6480464CTDBerberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR mRNA]; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR protein]PMID:35439518
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