Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	68533
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	MTOR
Name:	mechanistic target of rapamycin kinase

Acc ID:	CHEBI:45951
Term:	trifluoperazine
Definition:	A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Chemical ID:	MESH:D014268

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
MTOR	decreases phosphorylation	EXP		6480464	CTD	Trifluoperazine analog results in decreased phosphorylation of MTOR protein; Trifluoperazine results in decreased phosphorylation of MTOR protein	PMID:36702439 PMID:38360085
MTOR	multiple interactions	EXP		6480464	CTD	STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]	PMID:36702439
MTOR	multiple interactions	ISO	Mtor (Rattus norvegicus)	6480464	CTD	Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]	PMID:21544200
MTOR	multiple interactions	ISO	Mtor (Mus musculus)	6480464	CTD	Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]	PMID:21544200

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