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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68533
Species: Homo sapiens
RGD Object: Gene
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTORdecreases phosphorylationEXP 6480464CTDDextran Sulfate results in decreased phosphorylation of MTOR proteinPMID:31926917
MTORmultiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]PMID:31926917
MTORdecreases phosphorylationISOMtor (Mus musculus)6480464CTDDextran Sulfate results in decreased phosphorylation of MTOR proteinPMID:27611972 PMID:31926917
MTORincreases expressionISOMtor (Rattus norvegicus)6480464CTDDextran Sulfate results in increased expression of MTOR protein modified formPMID:32470352
MTORincreases expressionISOMtor (Mus musculus)6480464CTDDextran Sulfate results in increased expression of MTOR proteinPMID:26074695
MTORincreases phosphorylationISOMtor (Mus musculus)6480464CTDDextran Sulfate results in increased phosphorylation of MTOR proteinPMID:38648921
MTORmultiple interactionsISOMtor (Rattus norvegicus)6480464CTDcelastrol inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein modified form]PMID:32470352
MTORmultiple interactionsISOMtor (Mus musculus)6480464CTDbiochanin A inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MTOR protein]; CNR2 protein affects the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of MTOR protein]PMID:26074695 PMID:27611972 PMID:31926917 PMID:38648921
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