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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68431
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn5
Name: claudin 5
Acc ID: CHEBI:37454
Term: 9,10-phenanthroquinone
Definition: A phenanthrene that has formula C14H8O2.
Chemical ID: MESH:C005399
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn5decreases expressionISOCLDN5 (Homo sapiens)6480464CTD9,10-phenanthrenequinone results in decreased expression of CLDN5 mRNAPMID:34391839
Cldn5multiple interactionsISOCLDN5 (Homo sapiens)6480464CTD1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 protein]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine promotes the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 protein]; 9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein]; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein]PMID:34391839
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