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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68407
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrp2
Name: LDL receptor related protein 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp2affects expressionISOLRP2 (Homo sapiens)6480464CTDValproic Acid affects the expression of LRP2 mRNAPMID:25979313
Lrp2decreases expressionISOLRP2 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of LRP2 mRNAPMID:24383497 PMID:24935251 PMID:28001369
Lrp2decreases methylationISOLRP2 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of LRP2 genePMID:29154799
Lrp2increases expressionISOLRP2 (Homo sapiens)6480464CTDValproic Acid results in increased expression of LRP2 mRNAPMID:23179753 PMID:25192806 PMID:27188386
Lrp2increases expressionISOLrp2 (Mus musculus)6480464CTDValproic Acid results in increased expression of LRP2 mRNAPMID:19136453
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