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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:2979
Term: baicalein
Definition: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
Chemical ID: MESH:C006680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDbaicalein results in decreased expression of CCND1 proteinPMID:21457722 PMID:22820424 PMID:36988316
Ccnd1decreases expressionISOCcnd1 (Mus musculus)6480464CTDbaicalein results in decreased expression of CCND1 proteinPMID:24560969
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDbaicalein results in increased expression of CCND1 mRNAPMID:19160421
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDLithium Chloride inhibits the reaction [baicalein results in decreased expression of CCND1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA]PMID:19160421 PMID:22820424
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