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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:18406
Term: AICA ribonucleotide
Definition: A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.
Chemical ID: MESH:C031143
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtordecreases phosphorylationEXP 6480464CTDAICA ribonucleotide results in decreased phosphorylation of MTOR proteinPMID:27363783 PMID:28041982
Mtormultiple interactionsEXP 6480464CTDAICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]PMID:28041982
Mtordecreases activityISOMTOR (Homo sapiens)6480464CTDAICA ribonucleotide results in decreased activity of MTOR proteinPMID:19625624
Mtormultiple interactionsISOMtor (Mus musculus)6480464CTDAICA ribonucleotide promotes the reaction [Cadmium results in decreased phosphorylation of MTOR protein]PMID:21767558
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