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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68362
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrat
Name: lecithin retinol acyltransferase
Acc ID: CHEBI:17336
Term: all-trans-retinol
Definition: A retinol in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014801
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrataffects expressionEXP 6480464CTDVitamin A affects the expression of LRAT mRNAPMID:12576510
Lratdecreases expressionISOLrat (Mus musculus)6480464CTDVitamin A results in decreased expression of LRAT mRNAPMID:30944279
Lratincreases expressionISOLrat (Mus musculus)6480464CTDVitamin A results in increased expression of LRAT mRNAPMID:16292751
Lratmultiple interactionsISOLRAT (Homo sapiens)6480464CTD[STRA6 protein co-treated with LRAT protein] results in increased uptake of Vitamin APMID:18316031
Lratmultiple interactionsISOLrat (Mus musculus)6480464CTD[Vitamin A co-treated with Tetrachlorodibenzodioxin] results in increased expression of LRAT mRNA; Tetrachlorodibenzodioxin inhibits the reaction [Vitamin A results in increased expression of LRAT mRNA]PMID:16292751
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