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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631352
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr9
Name: toll-like receptor 9
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr9decreases expressionISOTlr9 (Mus musculus)6480464CTDOzone results in decreased expression of TLR9 mRNAPMID:26342085
Tlr9increases expressionISOTLR9 (Homo sapiens)6480464CTDOzone results in increased expression of TLR9 mRNAPMID:23665308
Tlr9multiple interactionsISOTlr9 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of TLR9 mRNAPMID:34911549
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