GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1h4 | affects response to substance | ISO | Nr1h4 (Mus musculus) | 6480464 | CTD | NR1H4 affects the susceptibility to yangonin | PMID:29660435 | Nr1h4 | increases expression | ISO | Nr1h4 (Mus musculus) | 6480464 | CTD | yangonin results in increased expression of NR1H4 mRNA | PMID:29660435 | Nr1h4 | multiple interactions | ISO | NR1H4 (Homo sapiens) | 6480464 | CTD | yangonin binds to and results in increased activity of NR1H4 protein | PMID:29660435 | Nr1h4 | multiple interactions | ISO | Nr1h4 (Mus musculus) | 6480464 | CTD | NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]]; NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]]; NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR1H4 protein] | PMID:29660435 | | ||||||||||||||||||||||
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