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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12b
Name: interleukin 12B
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12bincreases expressionISOIL12B (Homo sapiens)6480464CTDPoly I-C results in increased expression of IL12B proteinPMID:16890772
Il12bincreases expressionISOIl12b (Mus musculus)6480464CTDPoly I-C results in increased expression of IL12B mRNA; Poly I-C results in increased expression of IL12B proteinPMID:19426678 PMID:19500611
Il12bmultiple interactionsISOIL12B (Homo sapiens)6480464CTD[[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; [CL 075 co-treated with Poly I-C] results in increased secretion of [IL12A protein binds to IL12B protein]; [resiquimod co-treated with Poly I-C] results in increased secretion of [IL12A protein binds to IL12B protein]; [TL8-506 co-treated with Poly I-C] results in increased expression of IL12B mRNA; [TL8-506 co-treated with Poly I-C] results in increased secretion of [IL12A protein binds to IL12B protein]; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Poly I-C promotes the reaction [TL8-506 results in increased secretion of [IL12A protein binds to IL12B protein]]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]PMID:16890772 PMID:23266719 PMID:35688559
Il12bmultiple interactionsISOIl12b (Mus musculus)6480464CTDEthanol inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL12B mRNA]PMID:19426678 PMID:19500611
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