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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12b
Name: interleukin 12B
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12bmultiple interactionsISOIL12B (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]PMID:36416909
Il12bmultiple interactionsISOIl12b (Mus musculus)6480464CTDCyclosporine inhibits the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]PMID:17312158
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