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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12b
Name: interleukin 12B
Acc ID: CHEBI:230506
Term: apilimod
Definition: Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 in IFNg/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs. Apilimod is a potent and highly selective PIKfyve inhibitor.
Chemical ID: MESH:C504227
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12bdecreases expressionISOIL12B (Homo sapiens)6480464CTDapilimod results in decreased expression of IL12B mRNAPMID:21348542
Il12bmultiple interactionsISOIL12B (Homo sapiens)6480464CTDapilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL23A protein binds to IL12B protein]]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL12B protein]PMID:17053051 PMID:23890009
Il12bmultiple interactionsISOIl12b (Mus musculus)6480464CTDapilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL12B protein]PMID:23890009
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