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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:6757
Term: mephenytoin
Definition: An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Chemical ID: MESH:D008617
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3decreases activityISOCYP2B6 (Homo sapiens)6480464CTDMephenytoin results in decreased activity of CYP2B6 proteinPMID:9241656
Cyp2b3decreases activityISOCyp2b10 (Mus musculus)6480464CTDMephenytoin results in decreased activity of CYP2B10 proteinPMID:18420780
Cyp2b3decreases methylationISOCYP2B6 (Homo sapiens)6480464CTDCYP2B6 protein results in decreased methylation of MephenytoinPMID:12433797
Cyp2b3increases metabolic processingISOCYP2B6 (Homo sapiens)6480464CTDCYP2B6 protein results in increased metabolism of MephenytoinPMID:12464242
Cyp2b3multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTDMephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]; Mephenytoin inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Mephenytoin inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]PMID:25500267 PMID:9241656
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