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Term:
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(5R)-5-methylimidazolidine-2,4-dione 
(5S)-5-methylimidazolidine-2,4-dione 
(5S,5aR,8aS,8bR)-7-tert-butyl-5-(4-methoxyphenyl)-8b-methyl-2-(3-methylphenyl)-5a,8a-dihydro-5H-pyrrolo[1,2]pyrrolo[4,5-a]imidazole-1,3,6,8-tetrone 
(aminooxy)acetic acid  
1-(hydroxymethyl)-5,5-dimethylhydantoin 
1-[(5-nitro-2-furanyl)methylideneamino]imidazolidine-2,4-dione 
2-(2',5'-dioxo-1'-spiro[3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine]yl)-N-[4-[ethyl(propan-2-yl)amino]phenyl]acetamide 
2-(2,5-dioxo-4,4-dipropyl-1-imidazolidinyl)-N-(3-methoxyphenyl)acetamide 
2-(2,5-dioxo-4-imidazolidinyl)-N-(1-naphthalenyl)acetamide 
2-(4-butyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide 
2-[4-(2-furanylmethylidene)-2,5-dioxo-1-imidazolidinyl]-N-(4-methylphenyl)acetamide 
2-[4-(4-methoxyphenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]acetamide 
2-[4-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 
2-[4-[(3-ethoxy-4-hydroxyphenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]-N-(3-methylphenyl)acetamide 
2-[4-[4-(difluoromethoxy)phenyl]-4-methyl-2,5-dioxo-1-imidazolidinyl]acetic acid ethyl ester 
2-[[2-(4-ethyl-4-methyl-2,5-dioxo-1-imidazolidinyl)-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 
3,6,8-Trimethylallantoin 
3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile 
3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione 
3-[(2-fluorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]imidazolidine-2,4-dione 
3-[(4S)-2,5-dioxoimidazolidin-4-yl]propanoic acid 
3-[2-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-oxoethyl]-5-(2-methylpropyl)imidazolidine-2,4-dione 
3-[2-[[1-(3-chlorophenyl)-2,5-dioxo-4-imidazolidinylidene]methyl]-1-pyrrolyl]benzoic acid 
3-[2-hydroxy-3-(4-morpholinyl)propyl]-5,5-dimethylimidazolidine-2,4-dione 
4-[(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)methyl]benzoic acid methyl ester 
4-[2-[(2,5-dioxo-1-phenyl-4-imidazolidinylidene)methyl]-1-pyrrolyl]benzoic acid 
4-[5-[[1-[(2-chlorophenyl)methyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-2-furanyl]-3-methylbenzoic acid 
4-[[2-ethoxy-4-[(1-ethyl-2,5-dioxo-4-imidazolidinylidene)methyl]-6-prop-2-enylphenoxy]methyl]benzoic acid 
4-hydroxyphenytoin  
5,7-dihydroxy-4'-methoxyflavone +   
5-(2-furanylmethylidene)imidazolidine-2,4-dione 
5-(3,4-Dihydroxy-1,5-cyclohexadien-1-yl)-5-phenylhydantoin 
5-(4-hydroxybutyl)hydantoin 
5-[(1-ethyl-2,5-dimethyl-3-pyrrolyl)methylidene]-3-phenylimidazolidine-2,4-dione 
5-[(2,4,5-trihydroxyphenyl)methyl]imidazolidine-2,4-dione 
5-[[2,5-dimethyl-1-(3-pyridinyl)-3-pyrrolyl]methylidene]-3-phenylimidazolidine-2,4-dione 
5-chlorospiro[indole-3,2'-[1,3]oxathiolan]-2(1H)-one 
5-guanidinohydantoin 
5-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-5-phenylimidazolidine-2,4-dione 
5-methylimidazolidine-2,4-dione 
7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid +   
acetazolamide +   
adinazolam  
allantoin +   
Alloxanoic acid 4tms NIST 
alpha-asarone 
alprazolam  
amino(diphenylhydantoin) valeric acid 
aminoglutethimide +   
Azimilide  
azumolene 
brivaracetam 
carbamazepine +   
carnosine +   
CGP 78608 
CGP 78608 hydrochloride 
cinolazepam 
clobazam  
clodantoin 
clonazepam  
clorazepic acid 
D-5-monosubstituted hydantoin +  
dantrolene  
diazepam +   
diazolidinylurea 
didesethylflurazepam 
dipotassium clorazepate 
eslicarbazepine acetate 
estazolam  
ethosuximide +   
ethotoin +   
ezogabine  
felbamate  
flurazepam +   
Fosphenytoin 
furagin 
gabapentin +   
gabapentin enacarbil 
gamma-decalactone  
glutaurine 
glutaurine zwitterion 
glutaurine(1-) 
hentriacontan-16-one 
hispidulin  
hydantoin +   
hydantoin-5-propionic acid 
Hydroxymephenytoin  
Idanpramine 
iprodione  
L-5-carboxymethylhydantoin 
L-5-monosubstituted hydantoin +  
L-cycloserine +  
L-lysine +   
lamotrigine  
levetiracetam  
licarbazepine +  
magnesium sulfate +   
meclofenamic acid  
melatonin +   
mephenytoin  
An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
mephobarbital  
midazolam +   
midazolam hydrochloride 
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-methyl-2,5-dioxo-4-(2-phenylethyl)-1-imidazolidinyl]acetamide 
N-(3-cyanophenyl)-2-(4-ethyl-2,5-dioxo-4-phenyl-1-imidazolidinyl)acetamide 
N-(3-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 
N-(4-ethoxyphenyl)-2-[4-[2-(methylthio)ethyl]-2,5-dioxo-1-imidazolidinyl]acetamide 
N-(4-methylphenyl)-2-[4-[(5-methyl-2-thiophenyl)methylidene]-2,5-dioxo-1-imidazolidinyl]acetamide 
N-[3-(1-azepanylsulfonyl)phenyl]-2-[4-(1H-indol-3-ylmethyl)-2,5-dioxo-1-imidazolidinyl]acetamide 
N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-[4-methyl-4-(4-methylphenyl)-2,5-dioxo-1-imidazolidinyl]acetamide 
N-arachidonoylserotonin 
N-methylhydantoin 
nifurfoline 
nifurtoinol 
nimetazepam  
Nirvanol 
nitrazepam +   
nitrofurantoin  
nordazepam  
omeprazole +   
otophylloside B 
oxcarbazepine  
palmitoyl ethanolamide  
perampanel +  
perampanel hydrate 
phenobarbital +   
phenytoin  
phethenylate 
pregabalin  
prilocaine +  
primidone  
propofol +   
pyrrolidine dithiocarbamate  
RO4927350 
sodium meclofenamate monohydrate 
sodium selenate 
solasodine +   
solasodine(1+) 
thalidomide +   
thiopental  
tiagabine  
tiagabine hydrochloride 
topiramate  
trioctanoin 
troglitazone  
valproate semisodium 
valproic acid +   
vanillin +   
vigabatrin  
zaleplon  
zofenopril 
zofenopril calcium 
zofenoprilat 
zofenoprilat arginine 
zonisamide  

Synonyms
Exact Synonyms: 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
Related Synonyms: DL-Mephenytoin ;   Formula=C12H14N2O2 ;   InChI=1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16) ;   InChIKey=GMHKMTDVRCWUDX-UHFFFAOYSA-N ;   SMILES=CCC1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2 ;   mefenitoina ;   mephenytoine ;   mephenytoinum ;   methylphenetoin ;   phenylethylmethylhydantoin
Alternate IDs: CHEBI:91914
Xrefs: CAS:50-12-4 ;   Drug_Central:1695 ;   KEGG:D00375 ;   LINCS:LSM-1852
Xref Mesh: MESH:D008617
Xrefs: PMID:11422005 ;   PMID:15282764 ;   PMID:25797720 ;   PMID:29438107 ;   Reaxys:17282 ;   Wikipedia:Mephenytoin

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