GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ddit3 | increases expression | EXP | | 6480464 | CTD | perfluorooctanoic acid results in increased expression of DDIT3 mRNA | PMID:19162173 PMID:19407336 | Ddit3 | increases activity | ISO | DDIT3 (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in increased activity of DDIT3 protein | PMID:27589886 | Ddit3 | increases expression | ISO | Ddit3 (Mus musculus) | 6480464 | CTD | perfluorooctanoic acid results in increased expression of DDIT3 mRNA; perfluorooctanoic acid results in increased expression of DDIT3 protein | PMID:32578922 PMID:37044272 | Ddit3 | increases expression | ISO | DDIT3 (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in increased expression of DDIT3 mRNA; perfluorooctanoic acid results in increased expression of DDIT3 protein | PMID:19407336 PMID:34765786 PMID:35123991 PMID:36326898 | Ddit3 | multiple interactions | ISO | Ddit3 (Mus musculus) | 6480464 | CTD | 2-aminoethoxydiphenyl borate inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]; Acetylcysteine promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]; Dantrolene promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein]; KIRA6 inhibits the reaction [perfluorooctanoic acid results in increased expression of DDIT3 protein] | PMID:32578922 | | ||||||||||||||||||||||
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