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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:82664
Term: iron(0)
Definition: An elemental iron in which the atom has an oxidation state of zero.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases metabolic processingEXP 6480464CTDHIF1A gene mutant form results in decreased metabolism of IronPMID:16787915
Hif1aincreases response to substanceEXP 6480464CTDHIF1A protein results in increased susceptibility to IronPMID:16787915
Hif1adecreases expressionISOHif1a (Rattus norvegicus)6480464CTDIron deficiency results in decreased expression of HIF1A mRNAPMID:16629162
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTD[Deferoxamine results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA; [Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA; [Quercetin results in decreased abundance of Iron] which results in increased expression of HIF1A protein; Iron inhibits the reaction [galangin results in increased expression of HIF1A protein]; Iron inhibits the reaction [manganese chloride results in increased expression of HIF1A protein]; Iron inhibits the reaction [Nickel results in increased stability of HIF1A protein]; Iron inhibits the reaction [Quercetin results in increased expression of and affects the localization of HIF1A protein]; Iron inhibits the reaction [Quercetin results in increased expression of HIF1A protein]PMID:12393473 PMID:16877034 PMID:17364964 PMID:17973296 PMID:19263519 PMID:19729006
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