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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aincreases expressionEXP 6480464CTDmanganese chloride results in increased expression of HIF1A mRNA; manganese chloride results in increased expression of HIF1A proteinPMID:17467022 PMID:19263519
Hif1amultiple interactionsEXP 6480464CTD[[manganese chloride results in increased abundance of Manganese] which co-treated with Ethanol] results in increased expression of HIF1A protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HIF1A proteinPMID:34590183
Hif1adecreases degradationISOHIF1A (Homo sapiens)6480464CTDmanganese chloride results in decreased degradation of HIF1A proteinPMID:19263519
Hif1adecreases expressionISOHif1a (Rattus norvegicus)6480464CTDmanganese chloride results in decreased expression of HIF1A mRNAPMID:28801915
Hif1adecreases hydroxylationISOHIF1A (Homo sapiens)6480464CTDmanganese chloride results in decreased hydroxylation of HIF1A proteinPMID:19074761
Hif1aincreases expressionISOHIF1A (Homo sapiens)6480464CTDmanganese chloride results in increased expression of HIF1A mRNA; manganese chloride results in increased expression of HIF1A proteinPMID:17175027 PMID:19263519
Hif1aincreases stabilityISOHIF1A (Homo sapiens)6480464CTDmanganese chloride results in increased stability of HIF1A proteinPMID:19074761
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; [manganese chloride results in decreased activity of P4HTM protein] which results in decreased degradation of HIF1A protein; [manganese chloride results in decreased activity of P4HTM protein] which results in decreased hydroxylation of HIF1A protein; Ascorbic Acid inhibits the reaction [manganese chloride results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [manganese chloride results in increased stability of HIF1A protein]; HIF1A mutant form inhibits the reaction [manganese chloride results in increased secretion of VEGFA protein]; Iron inhibits the reaction [manganese chloride results in increased expression of HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]; manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; VHL protein affects the reaction [manganese chloride results in increased expression of HIF1A protein]PMID:19074761 PMID:19263519 PMID:20152896
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